BIO
-TWIN
Pharmacogenomic Safety Platform v2.0
Engine: 52 drugs | 7 CYP | Monte Carlo
API Key:
Patient Demographics
Age
Sex
Male
Female
Weight (kg)
eGFR (mL/min)
Hepatic Function
Normal (100%)
Mild impairment (70%)
Moderate (50%)
Severe (30%)
Active smoker (CYP1A2 induction)
Genetic Profile
CYP450 Enzymes
CYP2D6
*1/*1 (Normal)
*1/*4 (Intermediate)
*4/*4 (Poor)
*1/*10 (Intermediate)
*1xN/*1xN (Ultrarapid)
*1/*17
*4/*5 (Poor)
CYP2C19
*1/*1 (Normal)
*1/*2 (Intermediate)
*2/*2 (Poor)
*17/*17 (Ultrarapid)
*1/*17
CYP2C9
*1/*1 (Normal)
*1/*2 (Intermediate)
*1/*3 (Intermediate)
*2/*2 (Poor)
*2/*3 (Poor)
*3/*3 (Poor)
CYP3A4
*1/*1 (Normal)
*1/*22 (Intermediate)
*22/*22 (Poor)
CYP1A2
*1/*1 (Normal)
*1F/*1F (High)
*1/*1C (Reduced)
CYP2B6
*1/*1 (Normal)
*1/*6 (Intermediate)
*6/*6 (Poor)
CYP2C8
*1/*1 (Normal)
*1/*3 (Intermediate)
*3/*3 (Poor)
Non-CYP Enzymes
UGT1A1
*1/*1 (Normal)
*1/*28 (Gilbert's)
*28/*28 (Gilbert's)
DPYD
Normal
*2A/*2A (Deficient)
TPMT
*1/*1 (Normal)
*1/*3A (Intermediate)
*3A/*3A (Poor)
HLA Markers
HLA-B*57:01 (Abacavir)
HLA-B*15:02 (Carbamazepine/Phenytoin SJS)
HLA-A*31:01 (Carbamazepine)
Transporters
P-gp (ABCB1)
CC (Normal)
CT (Intermediate)
TT (Reduced)
OATP1B1 (SLCO1B1)
TT (Normal)
TC (Intermediate)
CC (Reduced)
Medications
Search Drug
Dose (mg)
Add Drug
Co-Medications (for DDI)
Quick Simulate
Generate PDF Report
Results
Add medications and click "Quick Simulate" or "Generate PDF Report" to see results.
Running simulation...